Page 16 - SOGIBA 1 2020

Caso Clínico

¿Qué es lo que añade este artículo? Las inmunoglobulinas intravenosas com-
Cuatrocientos miligramos diarios de hidroxi- binadas con el intercambio de plasma o solas
cloroquina iniciada antes del embarazo puede ser podrían ser utilizadas en mujeres embarazadas
una buena opción, especialmente en pacientes con SAF con complicaciones previas graves en
con SAF con una muerte fetal previa, sin compli- el embarazo.
caciones y refractaria a la terapia convencional.

REFERENCIAS

• Lassere M, Empson M. Treatment of antiphos- • Ruffatti A, Tonello M, Cavazzana A, Bagatella P,
pholipid syndrome in pregnancy–a systematic Pengo V. Labora- tory classification categories and
review of randomized therapeutic trials. Thromb pregnancy outcome in patients with primary anti-
Res 2004;114(5-6):419–426 phospholipid syndrome prescribed antithrom- bo-
• Sailer T, Zoghlami C, Kurz C, et al. Anti-beta2- tic therapy. Thromb Res 2009;123(03):482–487
glycoprotein I antibodies are associated with preg- • Ruffatti A, Tonello M, Visentin MS, et al. Risk
nancy loss in women with the lupus anticoagulant. factors for pregnancy failure in patients with anti-
Thromb Haemost 2006;95(05):796–801 phospholipid syndrome treated with conventional
• Fischer-Betz R, Specker C, Brinks R, Schneider therapies: a multicentre, case-control study. Rheu-
M. Pregnancy outcome in patients with anti- matology (Oxford) 2011;50(09):1684–1689
phospholipid syndrome after cere- bral ischaemic • Latino JO, Udry S, Aranda FM, Perés Wingeyer
events: an observational study. Lupus 2012;21 SDA, Fernández Romero DS, de Larrañaga GF.
(11):1183–1189 Pregnancy failure in patients with obstetric anti-
• Matsuki Y, Atsumi T, Yamaguchi K, et al. Clinical phospholipid syndrome with conventional treat-
features and pregnancy outcome in antiphospho- ment: the influence of a triple positive antibody
lipid syndrome patients with history of severe profile. Lupus 2017;26(09):983–988
pregnancy complications. Mod Rheumatol 2015; • Lockshin MD, Kim M, Laskin CA, et al. Prediction
25(02):215–218 of adverse pregnancy outcome by the presence

• Ruffatti A, Tonello M, Del Ross T, et al. Antibody of lupus anticoagulant, but not anticardiolipin
profile and clinical course in primary antiphos- antibody, in patients with antiphospholipid anti-
pholipid syndrome with pregnancy morbidity. bodies. Arthritis Rheum 2012;64(07):2311–2318
Thromb Haemost 2006;96(03):337–341 • Nodler J, Moolamalla SR, Ledger EM, Nuwayhid

14 Revista de Obstetricia y Ginecología de Buenos Aires